The present University Rector is Luigi Frati,  elected on 1 November 2008 for a four year term. The Rector is assisted by a Vice-Rector and a team of Deputy Rectors and Delegates in charge of different University activities. Two institutional Committees take part in the University governance: the Strategic Evaluation Team, providing support for programming activity, guidance and strategic control, and the University Evaluation Team, responsible for the evaluation of teaching and research.
The Sapienza governing bodies are two: the Academic Senate, in charge of academic, scientific and teaching issues and the Administration Board, in charge of financial and administrative issues.

The administrative structure is headed by the Head of Administration, who supervises organisation and management of the everyday activities of Sapienza. The structure is split into nine Divisions, dealing with different administrative areas.